Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials

BACKGROUND: Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of randomised trials which suggested that HRT reduced non-vertebral fractures by 30%. In this analysis we extend that analysis to vertebral fractures. METHODS: We searched the main electronic databases until the end of August 2001. We sought all randomised controlled trials (RCTs) of HRT where women had been randomised to at least 12 months of HRT or to no HRT. RESULTS: We found 13 RCTs. Overall there was a 33% reduction in vertebral factures (95% confidence interval (CI) 45% to 98%). CONCLUSIONS: This review and meta-analysis showed a significant reduction in vertebral fractures associated with HRT use

Massive planet migration: Theoretical predictions and comparison with observations

We quantify the utility of large radial velocity surveys for constraining theoretical models of Type II migration and protoplanetary disk physics. We describe a theoretical model for the expected radial distribution of extrasolar planets that combines an analytic description of migration with an empirically calibrated disk model. The disk model includes viscous evolution and mass loss via photoevaporation. Comparing the predicted distribution to a uniformly selected subsample of planets from the Lick / Keck / AAT planet search programs, we find that a simple model in which planets form in the outer disk at a uniform rate, migrate inward according to a standard Type II prescription, and become stranded when the gas disk is dispersed, is consistent with the radial distribution of planets for orbital radii 0.1 AU < a < 2.5 AU and planet masses greater than 1.65 Jupiter masses. Some variant models are disfavored by existing data, but the significance is limited (~95%) due to the small sample of planets suitable for statistical analysis. We show that the favored model predicts that the planetary mass function should be almost independent of orbital radius at distances where migration dominates the massive planet population. We also study how the radial distribution of planets depends upon the adopted disk model. We find that the distribution can constrain not only changes in the power-law index of the disk viscosity, but also sharp jumps in the efficiency of angular momentum transport that might occur at small radii.Comment: ApJ, in press. References updated to match published versio

Systematic review of topical treatments for fungal infections of the skin and nails of the feet

OBJECTIVE: To identify and synthesise the evidence for efficacy and cost effectiveness of topical treatments for superficial fungal infections of the skin and nails of the feet. DESIGN: Systematic review. INTERVENTIONS: Topical treatments for superficial fungal infections. MAIN OUTCOME MEASURES: Cure confirmed by culture and microscopy for skin and by culture for nails in patients with clinically diagnosed fungal infections. RESULTS: Of 126 trials identified in 121 papers, 72 (57.1%) met the inclusion criteria. Placebo controlled trials yielded pooled relative risks of failure to cure skin infections: allylamines (0.30, 95% confidence interval 0.24 to 0.38); azoles (0.54, 0.42 to 0.68); undecenoic acid (0.28, 0.11 to 0.74); and tolnaftate (0.46, 0.17 to 1.22). Although meta-analysis of 11 trials comparing allylamines and azoles showed a relative risk of failure to cure of 0.88 (0.78 to 0.99) in favour of allylamines, there was evidence of language bias. Seven reports in English favoured allylamines (0.79, 0.69 to 0.91), but four reports in foreign languages showed no difference between the two drugs (1.01, 0.90 to 1.13). Neither trial of nail infections showed significant differences between alternative topical treatments. CONCLUSIONS: Allylamines, azoles, and undecenoic acid were efficacious in placebo controlled trials. There are sufficient comparative trials to judge relative efficacy only between allylamines and azoles. Allylamines cure slightly more infections than azoles but are much more expensive than azoles. The most cost effective strategy is first to treat with azoles or undecenoic acid and to use allylamines only if that fails

Star Captures by Quasar Accretion Disks: A Possible Explanation of the M-sigma Relation

A new theory of quasars is presented in which the matter of thin accretion disks around black holes is supplied by stars that plunge through the disk. Stars in the central part of the host galaxy are randomly perturbed to highly radial orbits, and as they repeatedly cross the disk they lose orbital energy by drag, eventually merging into the disk. Requiring the rate of stellar mass capture to equal the mass accretion rate into the black hole, a relation between the black hole mass and the stellar velocity dispersion is predicted of the form M_{BH} \propto sigma_*^{30/7}. The normalization depends on various uncertain parameters such as the disk viscosity, but is consistent with observation for reasonable assumptions. We show that a seed central black hole in a newly formed stellar system can grow at the Eddington rate up to this predicted mass via stellar captures by the accretion disk. Once this mass is reached, star captures are insufficient to maintain an Eddington accretion rate, and the quasar may naturally turn off as the accretion switches to a low-efficiency advection mode. The model provides a mechanism to deliver mass to the accretion disk at small radius, probably solving the problem of gravitational instability to star formation in the disk at large radius. We note that the matter from stars that is incorporated to the disk has an average specific angular momentum that is very small or opposite to that of the disk, and discuss how a rotating disk may be maintained as it captures this matter if a small fraction of the accreted mass comes from stellar winds that form a disk extending to larger radius. We propose several observational tests and consequences of this theory.Comment: submitted to Ap

Scale-free equilibria of self-gravitating gaseous disks with flat rotation curves

We introduce exact analytical solutions of the steady-state hydrodynamic equations of scale-free, self-gravitating gaseous disks with flat rotation curves. We express the velocity field in terms of a stream function and obtain a third-order ordinary differential equation (ODE) for the angular part of the stream function. We present the closed-form solutions of the obtained ODE and construct hydrodynamical counterparts of the power-law and elliptic disks, for which self-consistent stellar dynamical models are known. We show that the kinematics of the Large Magellanic Cloud can well be explained by our findings for scale-free elliptic disks.Comment: AAS preprint format, 21 pages, 8 figures, accepted for publication in The Astrophysical Journa

Lopsided Galaxies, Weak Interactions and Boosting the Star Formation Rate

To investigate the link between weak tidal interactions in disk galaxies and the boosting of their recent star formation, we obtain images and spatially integrated spectra (3615A < lambda < 5315A) for 40 late-type spiral galaxies (Sab-Sbc) with varying degrees of lopsidedness (a dynamical indicator of weak interactions). We quantify lopsidedness as the amplitude of the m=1 Fourier component of the azimuthal surface brightness distribution, averaged over a range of radii. We compare the young stellar content, quantified by EW(H\delta_abs) and the strength of the 4000 Angstrom break (D_4000), with lopsidedness and find a 3-4 sigma correlation between the two. We also find a 3.2 sigma correlation between EW(H\beta_emission) and lopsidedness. Using the evolutionary population synthesis code of Bruzual & Charlot we model the spectra as an ``underlying population'' and a superimposed ``boost population'' with the aim of constraining the fractional boost in the SFR averaged over the past 0.5 Gyr (the characteristic lifetime of lopsidedness). From the difference in both EW(H\delta_abs) and D_4000 between the most and least symmetric thirds of our sample, we infer that ~ 1x10^9 M_solar of stars are formed over the duration of a lopsided event in addition to the ``underlying'' SFH (assuming a final galactic stellar mass of 10^10 M_solar). This corresponds to a factor of 8 increase in the SFR over the past 5x10^8 years. For the nuclear spectra, all of the above correlations except D_4000 vs. are weaker than for the disk, indicating that in lopsided galaxies, the SF boost is not dominated by the nucleus.Comment: 35 pages, including 10 figures, to appear in the Astrophysical Journal, abridged abstrac

The Lopsidedness of Present-Day Galaxies: Results from the Sloan Digital Sky Survey

Large-scale asymmetries in the stellar mass distribution in galaxies are believed to trace non-equilibrium situations in the luminous and/or dark matter component. These may arise in the aftermath of events like mergers, accretion, and tidal interactions. These events are key in the evolution of galaxies. In this paper we quantify the large-scale lopsidedness of light distributions in 25155 galaxies at z < 0.06 from the Sloan Digital Sky Survey Data Release 4 using the m = 1 azimuthal Fourier mode. We show that the lopsided distribution of light is primarily due to a corresponding lopsidedness in the stellar mass distribution. Observational effects, such as seeing, Poisson noise, and inclination, introduce only small errors in lopsidedness for the majority of this sample. We find that lopsidedness correlates strongly with other basic galaxy structural parameters: galaxies with low concentration, stellar mass, and stellar surface mass density tend to be lopsided, while galaxies with high concentration, mass, and density are not. We find that the strongest and most fundamental relationship between lopsidedness and the other structural parameters is with the surface mass density. We also find, in agreement with previous studies, that lopsidedness tends to increase with radius. Both these results may be understood as a consequence of several factors. The outer regions of galaxies and low-density galaxies are more susceptible to tidal perturbations, and they also have longer dynamical times (so lopsidedness will last longer). They are also more likely to be affected by any underlying asymmetries in the dark matter halo.Comment: 42 pages, 13 figures, 3 tables, accepted to Ap

Scalable N-body code for the modelling of early-type galaxies

Early-type galaxies exhibit a wealth of photometric and dynamical structures. These signatures are fossil records of their formation and evolution processes. In order to examine these structures in detail, we build models aimed at reproducing the observed photometry and kinematics. The developed method is a generalization of the one introduced by Syer and Tremaine (1996), consisting in an N-body representation, in which the weights of the particles are changing with time. Our code is adapted for integral-field spectroscopic data, and is able to reproduce the photometric as well as stellar kinematic data of observed galaxies. We apply this technique on SAURON data of early-type galaxies, and present preliminary results on NGC 3377.Comment: 6 pages, 2 figures. Original version printed in the Proceedings of "Science perspective for 3D spectroscopy", 2005, Eds Kissler-Patig, Walsh, Roth, ES0, Springe